Colorex KPC

Focus on KPC Resistance

KPC carbapenemase is an enzyme class, first found in Klebsiella pneumoniae isolates (hence, the name).

However, it can be produced by other organisms including Serratia spp., Enterobacter spp., E. coli, Citrobacter freundii and Salmonella enterica.

 

KPC resistance Epidemiologic Issues

Carbapenems are the last resort in treating many serious gram-negative infections. However, production of these enzymes results in resistance to penicillins, cephalosporins (i.e., cefepime, ceftriaxone), carbapenems (i.e., meropenem, ertapenem), and aztreonam, thereby making these pathogens truly multidrug-resistant and making their treatment very challenging.

 

Medium Performance

1. Detection of gram-negative bacteria expressing a reduced susceptibility to antibiotics of the carbapenem family.

2. Detection of NDM-1: this new resistance gene recently reported, has the ability of destroying carbapenems. Bacteria harbouring this resistance mechanism (a metallo-betalactmase) can easily be screened with Colorex KPC.

3. Species identification thanks to the Colorex™ Orientation base.

4. Time and workload savings: there is no need for a selective pre-enrichment medium. Direct plating of the sample is possible.

5. Requires only 18-24 hours of incubation.

6. Unique commercially available culture medium for the detection of bacteria having reduced suceptibility to carbapenems.

7. Flexibility: Colorex KPC Supplement is supplied with a shelf-life of about 2 years. This allows for flexibility of use, whether in an epidemic situation with many patients to screen, or whether for random surveillance of cultures.